Wigan Athletic will host Southampton after defeating Manchester City 1-0 on Monday to progress to the quarter-finals of the FA Cup.
Will Grigg was the hero, as the attacker slotted home in the 79th minute after City had been reduced to 10 men.
The last eight of the tournament triggers the business end of the competition, as Manchester United prepare to welcome Brighton & Hove Albion.
Premier League champions Chelsea travel to Leicester City, while Sheffield Wednesday or Swansea City face either Tottenham Hotspur or Rochdale after their respective replays.
Here is the full draw for the sixth round:
Sheffield Wednesday or Swansea City vs. Rochdale or Tottenham Hotspur
Manchester United vs. Brighton & Hove Albion
Leicester City vs. Chelsea
Wigan Athletic vs. Southampton
The last-eight fixtures will be played between Friday, March 16 and Monday, March 19.
Manchester United’s hiccups in the Premier League have again directed them to focus on cup competitions, and the Red Devils will face top-flight opposition when Brighton arrive at Old Trafford.
The Seagulls got to the final of the competition in 1983 but ran into United as they stood one hurdle from FA Cup glory.
Brighton took United to a replay after a 2-2 draw at Wembley Stadium, but the Manchester giants were ruthless as they won the game 4-0 under the captaincy of Bryan Robson.
As a promoted team, Brighton have performed well in their first season in the Premier League, and they lie 14th as the campaign heads down the final straight.
United can’t take their eye off the ball in the league, despite comfortably being in the top four most of the season, with Spurs just four points behind them in fifth.
Scott McTominay featured for United as they defeated Huddersfield Town in the fifth round on Saturday, and Red Devils manager Jose Mourinho was quick to praise the 21-year-old, per Simon Peach of the Press Association:
Mourinho on Scott McTominay: "Honestly, I think Scott deserves more than what he is getting. I think maybe it's because he's this kind of kid profile: a normal haircut, no tattoos, no big cars, no big watches, humble kid, arrive in the club when he was nine or 10" #MUFC
— Simon Peach (@SimonPeach) February 18, 2018
Leicester will fancy their chances when Chelsea visit the east Midlands in the next round.
Blues head coach Antonio Conte has endured a difficult second season in charge at Stamford Bridge, and his team are a shadow of the side that romped to the Premier League title last term.
The Foxes have recovered from a relatively bleak period and have thrived under the tenure of manager Claude Puel. The Frenchman has restored calm and order to the ranks.
Attacker Riyad Mahrez has remained at the club despite his expected departure in January, and the Algeria international will be a huge asset as they attempt to reach the semi-finals.
Jamie Vardy has remained productive up front, scoring 13 goals in 26 Premier League appearances this season.
Chelsea will need to be at their best to progress, but the west London side have appeared vulnerable on the road this season.
Spurs will be expected to see off Rochdale in their replay to claim a spot in the last eight, but either Sheffield Wednesday or Swansea will pose a significant threat.
As they chase the top four, and with the UEFA Champions League in full swing, the last thing the Lilywhites need is additional fixtures in the cup.
However, if they win their replay against Rochdale, they have an excellent chance of making it to Wembley for the final—a stadium they are now familiar with after using it as their home ground this season.
Manchester City’s exit is the shock of the competition so far, but Wigan deserved their victory after they battled tooth and nail with the Premier League leaders.
The Latics’ reward is a home clash against Southampton, and the League One side are just one victory away from an unlikely spot in the last four.